AVP and copeptin values were correlated with plasma osmolality using an in- house normogram allowing comparison of AVP response to a reference population 


The concentration of copeptin in the blood circulation ranges from 1 to 12 p mol /L in healthy individuals. The levels of copeptin are slightly higher in men than in women and are not influenced by age. In response to serum osmolality fluctuations, the kinetics of copeptin are comparable to those of vasopressin.

The potential biomarkers such as copeptin have to be always estimated in the context of a careful clinical assessment. Similar to many other biomarkers assessment of copeptin has certain limitations. Normal values of copeptin in healthy volunteers range between 1.70-11.25 pmol/L (6,9,10). Copeptin also shows minimal intra-individual variations (11). In healthy people, a 28h water deprivation leads to a twofold increase in concentration of copeptin, while infusion of hypotonic saline induces a 2-3-fold decrease of copeptin concentration (11).

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Similarly, copeptin concentrations in healthy volunteers of a population of 5000 individuals ranged between 1 and 13 pmol/L (upper 97.5 percentile) with median values <5 pmol/L [12] . In the first study including 359 subjects, plasma copeptin levels ranged from 1.0 to 13.8 pmol/L with a median concentration of 4.2 pmol/L. 13 The second evaluation with over 700 randomly selected volunteers reported comparable results with plasma copeptin levels ranging from 1.0 to 13.0 pmol/L.

(STEMI), and 52 healthy subjects (controls). Se- rum troponin-I, CK-MB mass, copeptin and CRP levels were measured in each of the cases, and.

Related FAQs: http://healthtopquestions.com/?p=674 http://healthtopquestions.com/?p=677 http://healthtopquestions.com/?p=1454 request uri=/what-is-the-normal-range-of-systolic-blood-pressure/ pn=what-is May 1, 2011 The indirect water deprivation test was considered normal if urine osmolality Patients with copeptin and AVP levels above the specific normal  Jan 8, 2009 The present study sought to identify confounding factors for the interpretation of copeptin levels in healthy individuals. The natriuretic peptides  Jun 18, 2014 The typical range of CTproAVP for patients with chronic or acute heart failure is between 10 and 50 pmol/L compared to the normal values of 4–7  Apr 8, 2013 P values for differences in copeptin tertiles were assessed with ANOVA for normally distributed continuous data, the Kruskal-Wallis test for  A low nocturnal level of vasopressin is thought to be one of the main causes of have low copeptin levels at night through the early morning, but normal levels  Copeptin plasma levels on admission ranged between 0.9 and 705.0 pmol·L−1 with a median (IQR) concentration of 13.7 (5.9–44.5) pmol·L−1.

Copeptin normal range

Copeptin plasma concentration in 359 healthy individuals were (median, range) 4.2 pmol/liter (1–13.8 pmol/liter). The 97.5th percentile was 11.25 pmol/liter, and the 2.5th percentile was 1.7 pmol/liter. Of all 359 tested volunteers, only nine (2.5%) had a plasma copeptin concentration below the detection limit of the assay of 1.7 pmol/liter.

Normal values and physiological response of plasma copeptin in healthy volunteers The reference range for copeptin was first defined in a study with 359 healthy volunteers. This study showed the broad range of copeptin values.

Levels of copeptin among elderly patients in relation to systolic heart failure and heart failure with normal ejection.
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Copeptin normal range

Statistical analysis.

Copeptin values according to normal plasma osmolality: Concentration range Intra-assay CV % Inter-assay CV % 2.0 – 4.0 pmol/L < 15.0 % < 18.0 % 4.0 – 15 pmol/L < 8.0 % < 10.0 % 15 – 50 pmol/l < 4.0 % < 5.0 % > 50 pmol/L < 3.0 % < 5.0 % Out of range samples (> 500 pmol/L) < 4.0 % < 6.0 % The normal range of plasma copeptin levels is from 1.0 to 13.8 pmol/l with higher median levels in men than in women according to two large physiological studies in healthy volunteers [26, 43].
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As a Control Group, 30 healthy individuals with normal physical examination results were included. In terms of blood copeptin levels, the result was 0.48 ± 0.27 ng/ml for the Control Group, 1.03 ± 0.56 ng/ml for Group 1, and 0.50 ± 0.32 ng/ml for Group 2.

Ann Neurol 2009;66:799-808. Distribution of copeptin is shown in Supplementary Figure S1, with a median value of 6.4 (3.8 to 11.0) pmol/l, and higher values in males than females. Subjects with higher copeptin had higher systolic and diastolic blood pressure, a higher body mass index as well as higher total kidney volume (TKV) and lower eGFR. 19 male and female subjects, aged 18–53 years (mean 25.8 years), participated in the study. Body weight of all subjects was within the normal range for age, sex, and height, and the BMI was in normal range between 18.5 and 24.9 kg/m 2. Each subject gave written informed consent for the study. Copeptin is a 39-amino acid glycopeptide derived from preprovasopressin and it is cosecreted in the bloodstream with vasopressin in an equimolar ratio in response to osmotic and hemodynamic changes.